Cuc, D.T. and Hien, N.T. and Doan, V.N. and Thuan, T.D. and Anh, D.T.T. and Thanh, N.H. and Ha, T.T. and Nga, N.T. and Tuyet, N.T.K. and Kiem, P.V. (2022) Design and Synthesis of New 2-Aminobenzamide Derivatives Containing Benzothiazole and Phenylamine Moiety and Their Cytotoxicity. Natural Product Communications, 17 (7).
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Twelve new compounds including 2-aminobenzamide derivatives bearing benzothiazole and phenylamine moiety were designed and synthesized. The synthesized compounds were tested their cytotoxic activity against A549 and SW480 tumor cell lines. Compounds 3a and 3c exhibited cytotoxicity toward A549 cell line with IC50 values of 24.59 and 29.59 µM, respectively. © The Author(s) 2022.
| Item Type: | Article |
|---|---|
| Divisions: | Faculties > Faculty of Physical and Chemical Engineering |
| Identification Number: | 10.1177/1934578X221116188 |
| Uncontrolled Keywords: | 2 aminobenzamide; 2 aminobenzamide derivative; aniline derivative; benzothiazole derivative; n 1 (2 aminophenyl) 3 methyl n 5 (4 tolyl)pentanediamide; n 1 (2 aminophenyl) n 4 (6 ethoxybenzodthiazol 2 yl)succinamide; n 1 (2 aminophenyl) n 4 (6 methoxybenzodthiazol 2 yl)succinamide; n 1 (2 aminophenyl) n 4 (6 methylbenzodthiazol 2 yl)succinamide; n 1 (2 aminophenyl) n 4 (benzodthiazol 2 yl)succinamide; n 1 (2 aminophenyl) n 5 (4 methoxyphenyl) 3 methylpentanediamide; n 1 (2 aminophenyl) n 5 (4 methoxyphenyl)glutaramide; n 1 (2 aminophenyl) n 5 (4 tolyl)glutaramide; n 1 (2 aminophenyl) n 5 (6 ethoxybenzodthiazol 2 yl)glutaramide; n 1 (2 aminophenyl) n 5 (6 methoxybenzodthiazol 2 yl)glutaramide; n 1 (2 aminophenyl) n 5 (6 methylbenzodthiazol 2 yl)glutaramide; n 1 (2 aminophenyl) n 5 (benzodthiazol 2 yl)glutaramide; unclassified drug, A-549 cell line; Article; controlled study; cytotoxicity; drug design; drug synthesis; IC50; SW480 cell line |
| URI: | http://eprints.lqdtu.edu.vn/id/eprint/10608 |
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