LE QUY DON
Technical University
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Optical properties of doxorubicin hydrochloride load and release on silica nanoparticle platform

Nguyen, T.N. and Nguyen, T.T. and Nghiem, T.H.L. and Nguyen, D.T. and Tran, T.T.H. and Vu, D. and Nguyen, T.B.N. and Nguyen, T.M.H. and Nguyen, V.T. and Nguyen, M.H. (2021) Optical properties of doxorubicin hydrochloride load and release on silica nanoparticle platform. Molecules, 26 (13): 3968. ISSN 14203049

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Abstract

Silica nanoparticles (SiO2 NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO2 NPs surfaces. The DOX·HCl loading onto and release from the SiO2 NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO2 NPs’ surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO2 NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO2 NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO2 NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO2 systems are good candidates for drug delivery and clinical applications. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type: Article
Divisions:
Faculties > Faculty of Physical and Chemical Engineering
Identification Number: 10.3390/molecules26133968
Uncontrolled Keywords: antineoplastic agent; doxorubicin; drug carrier; nanoparticle; silicon dioxide; chemistry; confocal microscopy; human; MCF-7 cell line; metabolism; neoplasm; pathology; Antineoplastic Agents; Doxorubicin; Drug Carriers; Humans; MCF-7 Cells; Microscopy, Confocal; Nanoparticles; Neoplasms; Silicon Dioxide
Additional Information: Language of original document: English. All Open Access, Gold, Green.
URI: http://eprints.lqdtu.edu.vn/id/eprint/8614

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