Anh, D.T.T. and Cuc, D.T. and Giang, L.N.T. and Hien, N.T. and Doan, V.N. and Thanh, N.H. and Van Tuyen, N. and Van Kiem, P. (2018) Design, synthesis and cytotoxic evaluation of novel lupane triterpenoid and ursolic acid derived 2-aminobenzamides. Natural Product Communications, 13 (7). pp. 817-822. ISSN 1934578X
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Abstract
Series of novel triterpenoid hybrids were designed and synthesized by introducing 2-aminobenzamide moiety at C28 position of triterpenoid derivatives. Thirteen new conjugates were thus successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity in KB and HepG2 cancer cell lines. © 2018 Natural Product Incorporation. All rights reserved.
| Item Type: | Article |
|---|---|
| Divisions: | Faculties > Faculty of Physical and Chemical Engineering |
| Identification Number: | 10.1177/1934578x1801300708 |
| Uncontrolled Keywords: | 2 aminobenzamide; 3a [(2 aminophenyl)carbamoyl] 1 isopropyl 5a,5b,8,8,11a pentamethyl 2 oxo 3,3a,4,5,5a,5b,6,7, 7 a , 8 , 9 , 10 , 11 , 11 a , 11 b , 12 , 13 , 13 a octadecahydro 2h cyclopenta[a]chrysen 9 yl acetate; 3a [(2 aminophenyl)carbamoyl] 5a,5b,8,11a tetramethyl 1 (prop 1 en 2 yl)icosahydro 1h cyclopenta[ a]chrysen 9 yl acetate; 8a [(2 aminophenyl)carbamoyl] 4,4,6a,6b,11,12,14b heptamethyl 1,2,3,4,4a,5,6,6a,6b,7,8,8a,9, 10,11,12,12a,14,14a,14b icosahydropicen 3 yl acetate; 9 hydroxy 5a,5b,8,8,11a penta methyl 1 (prop 1 en 2 yl)icosahydro 3ah cyclopenta[a]chrysen 3a yl methyl 5 [(2 aminophenyl)amino] 3 methyl 5 oxopentanoate; 9 hydroxy 5a,5b,8,8,11a pentamethyl 1 (prop 1 en 2 yl)icosahydro 3ah cyclopenta[a] chrysen 3a yl methyl 6 [(2 aminophenyl) carbamoyl]cyclohex 3 ene 1 carboxylate; 9 hydroxy 5a,5b,8,8,11a pentamethyl 1 (prop 1 en 2 yl)icosahydro 3ah cyclopenta[a]chrysen 3a yl methyl 4 [(2 aminophenyl)amino] 3,3 dimethyl 4 oxobutanoate; 9 hydroxy 5a,5b,8,8,11a pentamethyl 1 (prop 1 en 2 yl)icosahydro 3ah cyclopenta[a]chrysen 3a yl methyl 5 [(2 aminophenyl)amino] 5 oxopentanoate; 9hydroxy 5a,5b,8,8,11a pentamethyl 1 (prop 1 en 2 yl)icosahydro 3ah cyclopenta[a]chrysen 3a yl methyl 4 [(2 aminophenyl)amino] 4 oxobutanoate; antineoplastic agent; lupane triterpenoid; n (2 aminophenyl) 5a,5b,8,11a tetramethyl 9,12 dioxo 1(prop 1 en 2 yl)icosahydro 3ah cyclopenta[ a]chrysene 3a carboxamide; n (2 aminophenyl) 5a,5b,8,8,11a pentamethyl 9 oxo 1 (prop 1 en 2 yl)icosahydro 3ah cyclopenta[ a]chrysene 3a carboxamide; n (2 aminophenyl) 9 hydroxy 1 isopropyl 5a,5b,8,8,11a pentamethyl 2 oxo 2,3,4,5,5a,5b,6,7,7a, 8,9,10,11,11a,11b,12,13,13a octadecahydro 3ah cyclopenta [a]chrysene 3a carboxamide; n (2 aminophenyl) 9 hydroxy 5a,5b,8,11a tetramethyl 1(prop 1 en 2 yl)icosahydro 3ah cyclopenta[ a]chrysene 3a carboxamide; n (2 aminophenyl) 9 hydroxy 5a,5b,8,8,11a pentamethyl 1(prop 1 en 2 yl)icosahydro 3ah cyclopenta[ a]chrysene 3a carboxamide; unclassified drug; antineoplastic activity; Article; controlled study; cytotoxicity; drug design; drug effect; drug efficacy; drug mechanism; drug structure; drug synthesis; Hep-G2 cell line; human; human cell; KB cell line |
| Additional Information: | Language of original document: English. All Open Access, Bronze. |
| URI: | http://eprints.lqdtu.edu.vn/id/eprint/9553 |
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